Casino choice, like hotel choice, has a lot to do with personal preference -- it all depends on a gambler's favorite games, budget, and ability level. But a handful. Las Vegas is regionally known as “America's Playground.” Weekenders and Read our list to discover the best casinos in Las Vegas. Good luck!. U.S. News has identified top casino hotels by taking into account amenities, reputation among professional travel experts, guest reviews and hotel class ratings.